Conclusion CTGF can promote the transdifferentiation of human renal tubular epithelial cells towards myofibroblast ( MyoF) in vitro, and CTGF blockade results in a dramatic inhibition of TGF-β-induced transdifferentiation of renal tubular cells. 结论CTGF在体外能刺激肾小管上皮细胞向肌成纤维细胞(MyoF)转分化,而CTGF反义ODN的导入可有效抑制TGF-β1诱导的转分化过程。